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Package inserts and product labels for fenfluramine and dexfenfluramine—as well as for all of the other serotonin phentermine reuptake blockers — have stated unequivocally that these drugs are never to be administered along with an MAO inhibitor, lest free serotonin in the brain or blood rise to toxic levels and produce a “serotonin syndrome” or pathologic changes in vascular tissue .
In two important sites, the central nervous system and the lung, the combination of phentermine and a serotonin uptake blocker phentermine or releaser might be expected to cause major, if transient, increases in free (i .
Phentermine Inhibition phentermine other uses phentermine weight loss clinics sacramento ca adipex to lose weight adipex of Monoamine Oxidase FIG .
Concentration–inhibition curves phentermine of various drugs in rat liver homogenates .
Control MAO-A and MAO-B activities were 460 ⴞ 33 and 310 ⴞ 28 pmol/min/mg phentermine tissue, respectively .
Each point represents the mean ⴞ adipex doctor reviews adipex user reviews adipex meaning phentermine hcl legal duromine dosage for SEM of 4 experiments .
plasma phentermine or intrasynaptic) serotonin .
phentermine Neurochemical experiments show that MAO inhibition per se can increase extracellular serotonin  and enhance such serotoninmediated effects as anorexia  .
Similarly, phentermine alone suppresses appetite , increases phentermine extracellular serotonin levels [29, 30], and, when given in combination with serotoninergic agents such as fenfluramine, enhances their effects on appetite  and on extracellular serotonin levels  .
phentermine The effects of phentermine on extracellular brain serotonin levels, when given alone or combined with fenfluramine [29, 30], are compatible with its inhibitory action on MAO-A (Table 1) .
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