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    Package inserts and product labels for fenfluramine and dexfenfluramine—as well as for all of the other serotonin phentermine reuptake blockers [9]— have stated unequivocally that these drugs are never to be administered along with an MAO inhibitor, lest free serotonin in the brain or blood rise to toxic levels and produce a “serotonin syndrome” or pathologic changes in vascular tissue .
    In two important sites, the central nervous system and the lung, the combination of phentermine and a serotonin uptake blocker phentermine or releaser might be expected to cause major, if transient, increases in free (i .
    Phentermine Inhibition phentermine other uses phentermine weight loss clinics sacramento ca adipex to lose weight adipex of Monoamine Oxidase FIG .
    Concentration–inhibition curves phentermine of various drugs in rat liver homogenates .
    Control MAO-A and MAO-B activities were 460 ⴞ 33 and 310 ⴞ 28 pmol/min/mg phentermine tissue, respectively .
    Each point represents the mean ⴞ adipex doctor reviews adipex user reviews adipex meaning phentermine hcl legal duromine dosage for SEM of 4 experiments .
    plasma phentermine or intrasynaptic) serotonin .
    phentermine Neurochemical experiments show that MAO inhibition per se can increase extracellular serotonin [26] and enhance such serotoninmediated effects as anorexia [27] .
    Similarly, phentermine alone suppresses appetite [28], increases phentermine extracellular serotonin levels [29, 30], and, when given in combination with serotoninergic agents such as fenfluramine, enhances their effects on appetite [31] and on extracellular serotonin levels [30] .
    phentermine The effects of phentermine on extracellular brain serotonin levels, when given alone or combined with fenfluramine [29, 30], are compatible with its inhibitory action on MAO-A (Table 1) .

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